Abzu

Abzu: Revolutionizing Pharma R&D with Explainable AI

What is Abzu?

Abzu is a pioneering technology suite designed to transform pharmaceutical research and development (R&D), particularly in the realm of RNA therapeutics. By leveraging the power of explainable AI (XAI), Abzu offers a trustworthy and transparent approach to drug design, ensuring that scientists can understand and validate the AI's recommendations.

How does Abzu work?

Abzu employs a data-driven drug design process that takes into account a multitude of relevant factors often overlooked by traditional methods. These factors include thermodynamics, genetic variation, and various drug properties. Abzu's predictive models are trained and validated by experienced data scientists on curated datasets, resulting in high-quality compound designs tailored to specific needs. The QLattice®, a core component of Abzu's technology, generates siRNA activity models from publicly available data, providing insights that can be used to design active siRNAs.

Key Features and Benefits:

• AI-Guided Drug Design: Abzu's AI models predict critical drug properties such as activity, cross-reactivity, and off-target potential, allowing for the design of compounds with a higher likelihood of success.
• Data-Driven Approach: Predictive models are trained on curated data, ensuring accuracy and reliability.
• Ready-to-Use Compound Designs: Abzu delivers a list of ready-to-use compound designs along with a comprehensive report detailing the selection process and the rationale behind each choice.
• Integration of Existing Data: Abzu can incorporate data from previous experiments to further refine its models and improve results.
• One-Stop Solution: Abzu offers end-to-end services, from design to in vitro validation, reducing project management overhead and accelerating the development timeline.
• Scientific Approach to Data: Abzu designs experiments to ensure data quality, maximizing learning and reducing time-to-result.

Why Choose Abzu?

• Maximize Success Rates: By testing only the best compounds, Abzu increases the likelihood of successfully developing a drug.
• Faster Turnaround: Abzu reduces the time spent on designs destined to fail, accelerating the discovery process.
• Smart Models: Abzu's models incorporate existing learnings, providing a more informed and effective approach to drug design.
• Reduced Project Management Overhead: Abzu's comprehensive services streamline the drug design process.

Who is Abzu for?

Abzu is ideal for pharmaceutical companies, research institutions, and scientists involved in:

• RNA therapeutics design
• Drug discovery
• siRNA, anti-miRs, and ASO development
• Data-driven research

Practical Applications and Case Studies:

• RNA Therapeutics: Abzu has successfully designed active and safe ASO and siRNA therapeutics in strategic partnerships.
• LNP Designer: Abzu created a real-time LNP designer to predict apparent pKa values, allowing scientists to modify LNP properties and observe the direct impact.
• Safe ASO Design: Abzu increased safe ASOs by 20% over existing in-house models, demonstrating best-in-class activity models for RNA therapeutics.

What Sets Abzu Apart?

Abzu differentiates itself through its commitment to explainable AI, its comprehensive data-driven approach, and its ability to provide end-to-end solutions for drug design and validation. Abzu's services helps research and development teams achieve faster turnaround times for promising candidates, reducing design time and costs. The goal is to go directly from target identification to in vitro validated candidates, streamlining the entire drug design process.

Abzu’s method maximises learning by grounding its models in real-world results and reduces the overall time-to-result in a reliable way, giving a robust way to design RNA therapeutics.

How to Get Started with Abzu?

To explore how Abzu can transform your RNA designs, reach out to their team. Start leveraging high-quality data and predictive models to improve your designs today.

In conclusion, Abzu is a transformative AI-driven platform that empowers pharmaceutical R&D with trustworthy, explainable solutions for designing better RNA therapeutics. By focusing on data-driven approaches, predictive modeling, and end-to-end services, Abzu accelerates drug discovery and maximizes success rates for its partners.