Enki™

Enki™: Revolutionizing Drug Discovery with Generative AI

What is Enki™?

Enki™ is a cutting-edge generative AI platform developed by Variational AI, designed to transform the landscape of small molecule drug discovery. Unlike traditional methods that rely on screening vast libraries of existing compounds, Enki™ generates novel, synthesizable molecules tailored to specific therapeutic targets. This approach promises to significantly reduce timelines, lower costs, and unlock new possibilities in drug development.

How does Enki™ work?

Enki™ leverages a fully-trained generative AI foundation model to create target-specific compounds that go beyond the limitations of existing chemical libraries. The process involves several key steps:

1. Defining the Target Product Profile (TPP): Users specify the desired characteristics of the molecule, including on- and off-targets, as well as physico-chemical properties.
2. AI-Driven Compound Generation: Enki™ generates diverse and novel structures that meet the defined TPP criteria.
3. Selection and Optimization: Researchers select promising compounds for synthesis and testing. Enki™ can also perform hyper-efficient lead optimization within defined structural constraints.

This workflow enables rapid exploration of uncharted chemical space, accelerating the discovery of potential drug candidates.

Key Features and Benefits

• Generative AI, Not Screening: Enki™ creates new molecules de novo, eliminating reliance on existing libraries.
• Multi-Objective Optimization: The platform simultaneously optimizes for over 50 physico-chemical properties, including potency, selectivity, toxicity, pharmacokinetics (PK), synthesizability, and ADME (absorption, distribution, metabolism, and excretion).
• Designed for Early Discovery: Enki™ is purpose-built for early-stage drug discovery, facilitating the generation of first- and best-in-class compounds across multiple therapeutic areas.

Why is Enki™ important?

The chemical space of potential drug-like molecules is estimated to be an astonishing 10⁶⁰. Traditional drug discovery methods have only scratched the surface of this vast potential. Enki™ addresses this challenge by redefining the unit economics of drug discovery, leading to better patient outcomes.

By generating molecules instead of simply screening them, Enki™ transforms the cost, speed, and scope of small molecule drug discovery, starting with oncology.

Who is Enki™ for?

Enki™ is designed for R&D teams in the biopharmaceutical industry, particularly those focused on early-stage drug discovery. It is suitable for researchers aiming to:

• Discover novel compounds with specific target profiles.
• Accelerate lead identification and optimization.
• Reduce the cost and time associated with traditional drug discovery methods.
• Explore uncharted chemical space for innovative therapeutic solutions.

Variational AI: Transforming Drug Discovery with AI

Variational AI is a team of machine learning researchers, chemists, and biotech professionals dedicated to revolutionizing early drug discovery with generative AI. They collaborate closely with biopharmaceutical partners to develop new therapeutics across various disease areas.

Latest News and Events

Variational AI actively participates in industry events and conferences, showcasing their innovative approach to drug discovery. Recent events include:

• Discovery on Target 2025
• BIO-Europe 2025
• BioJapan 2025

Variational AI has also formed partnerships with companies like Life Chemicals to discover selective dual EGFR/FGFR1 inhibitors using generative AI.

Conclusion

Enki™ represents a significant advancement in the field of drug discovery. By leveraging the power of generative AI, Variational AI is enabling researchers to explore the vast potential of chemical space and accelerate the development of new therapeutics. For R&D teams seeking to transform their drug discovery process, Enki™ offers a powerful and innovative solution. Consider Enki™ if you are looking for the best way to generate novel, synthesizable compounds tailored to your Target Product Profile.